9-year-old Sheldon Cooper is a once-in-a-generation mind capable of advanced mathematics and science but learns that isn’t always helpful growing up in East Texas, a land where church and football are king.

To appease his worried mother, Sheldon employs the techniques of a self-help book to try and make a friend.

When George Sr. is rushed to the emergency room, Connie comes to babysit, and the kids have an adventure getting to the hospital on their own.

After choking on a breakfast sausage, Sheldon wrestles with his fear of solid foods and discovers comic books for the first time.

Sheldon struggles with newfound popularity after utilizing statistics to help the football team.

When a NASA representative visits Sheldon’s school and dismisses his science, Sheldon is set on a mission to prove him wrong.

The kids brainstorm ways to resolve a family feud when Connie refuses to give George Sr. her brisket recipe.

While Mary, Connie and Missy have their girls night at the salon, the three Cooper men plan their road trip to see the space launcher, but it doesn't go as well as they plan.

George Sr. strikes a deal with Sheldon to tutor Georgie when poor grades threaten to keep him from playing football. While Sheldon's tutoring attempts are ultimately unsuccessful, he does learn some skills from his brother.

When Sheldon moves to Dallas to attend a school for gifted children, the family struggles to cope with his absence.

A worried Mary sends Sheldon to Sunday school after she finds him playing Dungeons and Dragons with his friends, Tam and Billy.

Sheldon asks for a computer and unknowingly sparks a heated argument between Mary and George Sr. over the family’s finances.

When flu season hits Medford, Sheldon takes extreme measures to remain healthy.

When Mary takes a job as church secretary, she finds herself becoming Pastor Jeff's marriage counselor. Also, Sheldon and Missy spend their first afternoon home alone.

Sheldon makes friends with an upperclassman who introduces him to a new field of science. Also, Mary and George disagree on how to handle Sheldon's blossoming social life.

A disappointing loss at the science fair sends Sheldon’s life in a new direction.

Sheldon is bullied by an unlikely character, and Mary and George disagree on how to handle the situation.

Mary bans Sheldon from reading a mature comic book. Sheldon decides it's time to stop living under Mary's thumb.

When Sheldon is no longer academically challenged at Medford High, he audits a college class taught by Dr. John Sturgis.

A battle erupts between the Coopers and Sparks when the Sparks' new dog terrorizes Sheldon.

While Sheldon is busy keeping tabs on Connie’s budding relationship with Dr. Sturgis, George Sr. and Mary attempt to bond with their other children.

When Connie is pursued by two gentlemen callers, Sheldon interferes, forcing her to set some ground rules.

After Sheldon dismantles the refrigerator to stop an annoying hum, he gets a paper route to pay for the repairs.

When Dr. Sturgis bonds with Paige, another 10-year-old genius, Sheldon’s jealousy leads Connie to intervene. Mary invites Paige’s family over for a play date.

When Mary’s faith is shaken by a tragedy in the community, Sheldon becomes an unlikely ally.

When George Sr. asks Sheldon to keep a secret from Mary, the stress of not being honest drives Sheldon to hideout at Tam’s for his first sleepover.

When Dr. Sturgis recommends Sheldon and Missy for a university research study on twins, Mary is unhappy when the test results go to Sheldon's head.

Mary clashes with Sheldon's drama teacher over plans for a Halloween fundraiser for the church. Georgie falls for a rebellious teenage girl whom Sheldon is tutoring.

Sheldon gets into trouble with fellow child genius, Paige at the science museum. George is forced to play therapist to Paige’s bickering parents. Mary, Georgie and Missy help Connie with a garage sale.

A video game takes over Sheldon and Connie’s life. George Sr. is jealous when Georgie bonds with Herschel at the auto shop.

Sheldon studies his family for a psychology project. Thanksgiving dinner turns into a family fight when George Sr. is offered a job in Oklahoma.

When Sheldon learns that people with stunted childhoods can turn into social outcasts, he tries to act. Connie and Dr. Sturgis' relationship is tested when she teaches him how to drive.

Sheldon experiments on Missy, and Georgie joins Mary’s bible study to spend more time with his crush, Veronica.

When Sheldon has to spend a few days in the hospital, he turns into the world’s worst patient. Also, Missy gets a taste of what life would be like without her twin.

Sheldon attempts to build a nuclear reactor. Also, a university cocktail party gets heated when Dr. Sturgis’ colleague, Dr. Linkletter, flirts with Connie, and Georgie is heartbroken when he learns Veronica has a boyfriend.

Sheldon uses his new friendship with the school bully to boss Georgie around. Also, Missy steals Connie's makeup for picture day.

Sheldon and Dr. Sturgis have their first fight when Dr. Sturgis marks a question wrong on Sheldon's test. Also, Mary takes over for Pastor Jeff when he's out sick.

Things spiral out of control when Sheldon boycotts his favorite bread company. Also, Georgie offers Veronica a shoulder to cry on when she's dumped by her boyfriend.

Inspired by his hero, Albert Einstein, Sheldon tries his hand at the violin. Also, Mary and Connie secretly buy a pregnancy test when Mary thinks she's pregnant

Sheldon moves in with Dr. Sturgis for the weekend to see what his life will be like in college. Also, a lonely Mary tries to bond with the other Coopers during Sheldon's absence.

Unhappy that school funds are going towards football rather than academics, Sheldon decides to run for class president.

Georgie is thrilled when Veronica stays at the Coopers' house for a few days. Also, Connie and Dr. Sturgis celebrate their one-year anniversary.

The Coopers help Pastor Jeff through a rough patch in his marriage. Also, Sheldon pressures church members for donations when Mary takes him to work for a day.

Sheldon invites the entire school to a party for the Nobel Prize announcements. Also, Connie learns more about Dr. Sturgis' past, and Georgie's desire for cable TV leads to a standoff between him and George Sr.

After Dr. Sturgis experiences a nervous breakdown, Mary worries Sheldon is headed down a similar path. Also, Georgie discovers he has a knack for sales.

Without Dr. Sturgis’ university class, Sheldon must find a new way to stay academically challenged. Also, Mary helps Pastor Jeff avoid temptation with his girlfriend.

Sheldon takes matters into his own hands when Connie refuses to drive him to a lecture with Dr. Linkletter. Also, Georgie tries to impress Veronica with his new business venture

Sheldon is forced to take a break from science when his new obsession with "The Lord of the Rings" leads to an unhealthy habit. Also, Missy asks George Sr. to teach her how to play catch.

After being released from the mental hospital, Dr. Sturgis unexpectedly breaks up with Connie.

A church carnival leads Missy to try out for the baseball team. Also, Connie struggles after her breakup with Dr. Sturgis.

Sheldon starts an internet flame war, and Missy stands up to the boys on her baseball team. Also, Connie is unhappy when George Sr. spends time with her new boyfriend.

The University makes George Sr. a lucrative job offer in the hopes of recruiting Sheldon. Also, Georgie gets a job working for Connie's new boyfriend, and Mary is determined to rid her home of greed.

Mary gets Pastor Jeff involved when Sheldon isn't invited to Billy's birthday party. Also, George Sr. has "male-bonding time" with Dr. Sturgis.

Sheldon fakes being sick to avoid a swim test at school. Also, Dr. Sturgis spies on Connie's new boyfriend.

George Sr. and Connie struggle to manage the Cooper household while Mary plans Pastor Jeff’s wedding.

Sheldon learns to listen when an emotional Paige struggles with her parents’ divorce. George Sr. is furious when Georgie tries to buy his way out of chores.

George Sr. and Georgie go camping with Connie's new boyfriend, Dale, but things get complicated when her ex-boyfriend, Dr. Sturgis, tags along. Also, Sheldon and Missy invent a super-game.

Sheldon and Georgie mine for platinum in roadside gravel. Mary is concerned when Missy misuses religion to help with a batting slump.

Connie meets Dale’s ex-wife, June. Sheldon is forced to work on a group project with reluctant college students.

Sheldon visits CalTech for the very first time. Also, Georgie is furious when Mary listens in on a phone call with his girlfriend, and Connie tries to cheer up a jealous Missy.

Dr. Sturgis is furious when Sheldon accuses him of plagiarism. Also, Mary sets out to find a “girl trophy” for Missy’s end-of-season baseball ceremony, and Georgie has an awkward run-in with Veronica while on a date with his new girlfriend, Jana.

When George Sr. accidentally lands the school librarian in the hospital, the Cooper family must nurse her back to health. Connie gives Georgie relationship advice.

When Sheldon learns the house next door is for sale, he takes it upon himself to find the perfect neighbors. Missy is torn when she’s forced to pitch against her boyfriend at the baseball game.

Sheldon has a scientific breakthrough at the dentist's office. Also, Dale and Connie go to the casino, and Georgie makes a big mistake when Dale leaves him in charge of the store

Sheldon discovers that Mary's been keeping a secret about his future. Also, Connie is furious when she learns Dale fired Georgie.

After graduating high school, Sheldon has a breakdown when he realizes he may not be ready for college. Dale tries to make amends with Connie.

Sheldon gets a summer job at the local train museum. Also, George and Missy bond when Missy embarks on a new stage of womanhood, and Georgie discovers Mary's guilty pleasure.

With college in sight, Sheldon is determined to ride his bike without training wheels. Also, Mary and George Sr. argue over parenting styles.

When their mothers force them to attend Vacation Bible School. Also, George is furious after Georgie makes a questionable purchase.

Dale and Connie work out relationship issues while playing Dungeons and Dragons with Sheldon and Missy. Also, Mary and George take a trip with Coach Wilkins and his wife, and Georgie freaks out when his girlfriend thinks she's pregnant.

College orientation does not go as Sheldon planned. Also, Mary is invited to a party when she's mistaken for a university student, and George Sr. helps Pastor Jeff set up a children's nursery.

Sheldon's first day of college is derailed by his new philosophy teacher, Professor Ericson. Also, Mary and Brenda live vicariously through Missy's first day of middle school.

Connie takes matters into her own hands when Sheldon's philosophy teacher, Professor Ericson, sends him into a tailspin. Also, George Sr. learns Georgie has been cutting class.

Sheldon and George Sr. dine with President Hagemeyer and a university benefactor. Also, Georgie gives Missy some brotherly advice when Mary won't let her go to the school dance, and Dale and June convince Connie to attend their son's wedding.

Sheldon campaigns to become Dr. Linkletter's lab assistant. Also, Georgie enlists the help of Mr. Lundy, the drama teacher, for a surprising business venture.

Dr. Linkletter pushes Sheldon to make friends with his fellow students at college. Also, Georgie gets a pager.

Sheldon, Dr. Linkletter and Connie team up on a science experiment. Also, Mary is jealous that Pastor Jeff and Brenda are spending time together, and Georgie has a new side hustle.

Sheldon refuses to ride in a car after getting into an accident with Connie. Also, Missy uses their trauma to her advantage at school and Connie is forced to take the church shuttle while her car is in the shop.

When the IRS accuses Sheldon of making a mistake, he'll stop at nothing to prove them wrong. Also, Dale is forced to get a colonoscopy and tries to convince Connie to join him.

Sheldon is caught in a moral dilemma when offered a bootleg copy of a computer game he can't afford. Also, Mary and Connie take Brenda out for girls' night while George Sr. and the guys watch Billy, and Missy asks Georgie to take her and Marcus on a secret date.

Sheldon finds himself at odds with Paige once again when she considers enrolling at East Texas Tech. Also, Mary seeks June's advice when looking for a change.

The Coopers discuss the possibilities of black holes and alternate universes when Dr. Sturgis comes over for dinner.

Missy's first heartbreak triggers a series of events that lead the Cooper family to the brink.

Sheldon and Missy both run away from home, and Mary gets upsetting news about George Sr.

Sheldon encourages Missy to question the Bible. Also, Connie is determined to catch George Sr. in a lie, and Mary helps Pastor Jeff search for a youth pastor.

Sheldon tries to convince Dr. Sturgis to return to the university. Also, Georgie upsets the family when he makes a life-changing decision.

Sheldon, Missy and Georgie adapt to new living arrangements. Also, Connie opens a gambling room.

Sheldon and Dr. Linkletter struggle to solve an equation. Also, Georgie has a solution for Connie's business woes, and George Sr. gives advice on Missy's love life.

Missy asks some uncomfortable questions at church, and Connie and Georgie go into business together.

Sheldon takes his first engineering class with Professor Boucher. Also, Meemaw and Dale help take care of his ex-wife, June.

Sheldon battles President Hagemeyer's mysterious boss over the university's science requirements. Also, Mary discovers that Georgie is working at Connie's illegal gambling room.

Sheldon gets the science yips and has to learn how to not think. Also, George Sr. plays handyman at Brenda Sparks' house.

Sheldon gets a dorm room all to himself. Also, Connie gains an unwanted business partner.

Sheldon acts as Mary's spy during a youth lock-in at church. Also, Georgie is attracted to an older woman, Mandy.

Sheldon attends his first comic book convention; Mary tries selling makeup.

Sheldon makes friends with his dorm neighbors; George Sr. learns his job is in jeopardy.

Sheldon butts heads with Dr. Lee, a new scientist in the lab. Also, Mary is given a lotto ticket.

Sheldon joins Dr. Linkletter and Dr. Sturgis on a science road trip. Also, Georgie continues to lie about his age.

Connie's gambling room is a success, and Sheldon dips his toe in the stock market. Also, Missy starts a business.

Sheldon gets an odd request from an old friend, Paige. Also, George Sr. and Mary are caught in the middle of Connie and Dale's breakup, and Georgie comes clean to Mandy.

Sheldon copes with the death of a hero. Also, Missy wants to babysit, and Georgie struggles with his big secret.

George and Mary insist on meeting the new woman in Georgie's life. Also, Sheldon and Missy have suspicions about what's going on with their family.

Sheldon and Missy learn about Georgie's pregnancy, and the whole family promises to keep it a secret.

As the church congregation gossips about Georgie, Missy stands up for her brother, and Sheldon is distracted by the family drama.

Sheldon struggles to cope with the first signs of puberty. Also, Mary and George Sr. hunt for new jobs, and Georgie and Meemaw take a business trip across the border.

George Sr. bails Connie and Georgie out of jail. Also, Sheldon and Missy meet Mandy, and Mary feels unwelcome at church.

Sheldon and Missy try to help the family’s finances. Also, Mary struggles to find her footing without the church.

Sheldon must choose sides in an ethical dilemma. Also, Mary tries her hand at writing and Mandy needs a new place to live.

Sheldon makes a terrifying mathematical discovery while tutoring Billy. Also, Mary is jealous of Missy's relationship with Mandy and Connie.

At college, Sheldon decides to expand his responsibilities and become a dorm resident advisor. Also, Connie and Dale make a sketchy business deal, and Mary and George Sr. rekindle their romance.

George Sr. is asked to help with the football team. Also, Mandy discovers Georgie and Connie's secret business.

Sheldon's search for a comic book leads him to a breakthrough. Also, Georgie and Mandy have an uncomfortable first encounter with her parents, Jim and Audrey.

Sheldon's database invention puts him at odds with the university. Also, the church takes issue with Connie's video store.

Sheldon considers dropping out of college to focus on building his database. Also, George Sr. is frustrated when someone else gets credit for his football wins.

Mary struggles to make new friends while Mandy pushes Georgie to date another woman.

Sheldon learns the university is building a database without him. Also, Mary takes care of a bedridden Mandy and Meemaw.

Mary butts heads with Mandy's mother, Audrey, and Sheldon attempts male bonding.

Paige drags Sheldon to a college party and Missy gets caught in a lie.

The Coopers can't be found as Mandy goes into labor. Also, Sheldon is excited about the launch of his database.

Sheldon confronts the failure of his database. Also, Georgie and Mandy struggle as new parents and Missy feels forgotten.

Missy steals her dad's truck and hits the road with her friend Paige.

Georgie goes on a birthday date and Mary confronts Brenda about her relationship with George. Also, Sheldon takes an interest in Missy's favorite TV show.

Sheldon wants to search for life on other planets and Mandy answers Georgie's marriage proposal. Also, Missy is caught between two friends.

Mandy gets an exciting job opportunity and Sheldon worries that he's falling behind. Also, Georgie takes his daughter to work.

The gambling room gets broken into and Sheldon wants to study abroad. Also, Missy makes a new friend.

Mandy surprises Georgie with a spa weekend and Sheldon prepares for his summer in Germany.

Sheldon and Mary head to Germany while the rest of the Cooper family braves a tornado that is heading straight for Medford.

News of the tornado reaches Sheldon and Mary in Germany. Also, with the Cooper house in chaos, Missy steps up.

Sheldon realizes he is the weakest student in his class; Meemaw is looking to expand her gambling business.

Sheldon explores Germany behind Mary's back, Missy attempts to pull a fast one on George Sr. and Meemaw and Dale adjust to living together.

Missy steps up, Mary has a surprise for George, and Sheldon finds his dorm occupied.

Sheldon helps his roommate try to beat the stock market, Missy and Billy Sparks throw a party, and Mary finds a new church.

Georgie and Mandy's wedding plans pit Mary against Mandy's mom, Audrey, with baby CeeCee caught in the middle.

Georgie and Mandy get married! Meanwhile, Meemaw's gambling room gets raided.

Sheldon studies to be Meemaw's lawyer when she is put on house arrest, and the Coopers have a plumbing emergency.

Sheldon's published paper leads to a frenzy of grad school recruiting, and Georgie tries to speak more properly in front of his daughter.

Connie gets assigned a tough probation officer, and Georgie takes marriage advice from his father-in-law.

George Sr. is worried that Mary wants another baby and gets a vasectomy behind her back. Meanwhile, Drs. Linkletter and Sturgis go to Sheldon for science tutoring.

George Sr. gets an exciting job offer, and Sheldon prepares for his move to California.

The Cooper family grapples with the death of George Cooper Sr.

Sheldon leaves East Texas for the California Institute of Technology following the death of his father.