Season two opens with a bang as the Gregsons' neighbor commits suicide and the family unexpectedly is given responsibility of the house. Now well and dissociation-free for several months, Tara sets out to make new friends with Max's help. Marshall struggles to fit in at school while Kate lands a new job. Nick pops the question to Charmaine

Tara realizes her alternate personalities are emerging again, but keeps it a secret. Newly engaged Charmaine asks to move in with Tara and her family. Max decides to take on a new project by buying the neighbor’s house to flip it. Kate meets a mysterious older woman, Lynda (Viola Davis), while Marshall begins a new relationship… with a girl

The family discovers the truth -- Tara’s alternate personalities are back. Buck’s actions have brought serious consequences that unleash a new side of Max. Neil finds out about Charmaine’s engagement. Marshall and Courtney begin to experiment as Kate grows closer to Lynda.

Tara sets out to find a new therapist as Max struggles to come to terms with Buck’s affair. Marshall and Courtney take their relationship to the next level. Tara and Max disapprove of Kate’s friendship with Lynda. Charmaine tells the family some big news. A new alternate personality is born.

Max’s violent outburst comes back to haunt him. Tara learns she is now able to be aware of what her newest alternate personality, Shoshana, does. Kate’s music video is an internet success. Marshall decides he has to break up with Courtney. The doctor gives Charmaine surprising news about her pregnancy.

A tornado brings some long-covered secrets to light when Tara's alter Shoshana takes over.

An upcoming visit from a social worker has its effect on Max. Disapproving Kate's friendship with Lynda, Tara interferes while Neil learns that Charmaine is pregnant.

Tara and Lynda make preparations for their art show. Kate sets up a new business, while Lionel and Marshall's friendship deepens. In the meantime, Charmaine struggles trying to balance Neil and Nick.

Tara starts working on a family portrait in order to re-connect with her family while Max tries to get away from Pammy.

Tara and Charmaine discuss Tara's childhood memories with their mother and Max holds an open house after re-modeling their neighbor's house.

Tara and Charmaine pay a woman who appeared in Tara's memories a visit, while Kate tries to change herself for her new and much older boyfriend.

On the day of Charmaine and Nick's wedding, long-held secrets come to light, while Kate and Marshall accidentally make a discovery of consequence.

Max is worried when Tara returns to college to finish her college degree. Meanwhile, Charmaine with a baby on the way is avoiding a commitment to Neil, Kate tries to figure out a plan for her future and Marshall and Lionel sign up for a filmmaking class.

Her psychology professor humiliates Tara when she transitions in his class. Meanwhile, Kate considers giving English lessons in Japan and Max gets a business offer.

The stress of juggling school and Charmaine's baby shower causes Tara to transition, with negative consequences for Charmaine. To sell the family business, Max must get the approval of his eccentric mother. Kate meets a flight attendant who inspires a new idea about her future.

Tara and Charmaine are rushed to the hospital in the same ambulance, where Charmaine declares her baby off limits to her crazy sister; Tara attempts to make a deal with her alters, which intrigues her Abnormal Psychology professor; Marshall, Lionel and Noah put Charmaine's empty house to some creative uses; Kate is embarrassed to confess that she backed out of going to Japan.

Tara tries to drop her Abnormal Psychology class but instead receives an intriguing pitch from her instructor, Dr. Hattaras; Charmaine and Neil find parenthood a struggle but still refuse Tara's help; Max finds himself at odds with his boss at his new job; Kate prepares for flight attendant training; Lionel catches Marshall with Noah, jeopardizing their student film project.

Tara seems to be making progress with her new contract but Dr. Hattaras discovers something disturbing in a tape from one her therapy sessions; much to the sisters' chagrin, Neil invites Tara and Charmaine's mother to visit her grandchild; Max is unhappy at his new job but can't talk to Tara about it; Kate is surprised when a handsome flyer rebuffs her flirting.

Tara motivates Max to relive his old rock band Beaverlamp. Meanwhile, a depressed Dr. Hattaras makes her take a break from their therapy sessions and Marshall and Noah interview Max for their film festival project.

A new alter comes to light that put Charmaine's new baby at risk. Soon later, Alice visits Dr. Hattaras and intrigues him in Tara's case again. Kate, Max and Marshall fly to New York where they get to meet Kate's new friend Evan and his son.

The discovery of Tara's new dangerous alter makes Dr. Hattaras and Tara consult another professional. Marshall finds out that his short film hurt his father's feelings and Charmaine connects with "chic moms," while Kate tries to make her relationship with Evan work.

Max and Marshall return home from New York to bad news on all sides. Max learns of the new alter, Bryce, but a highly medicated Tara assures him all in under control. Marshall learns that a close friend has been killed in an accident. Tara offers support, which he gladly accepts, but on the day of the funeral Bryce emerges and apparently will not go away. It's all too much for Kate and Marshall who look to strike out on their own.

When Bryce takes over, Tara's new alter threatens to destroy the whole family. When Tara's other alters disappear one by one, Max decides to fight off Bryce before it's too late for Tara.

Tara re-emerges but the task now is to repair broken family relationships, particularly with Marshall who is fed up with it all. Rather than go into a local mental health facility, she decides to follow Dr. Hatteras' advice and see a specialist in Boston. Neil and Charmaine are moving to Houston and offer to take Marshall with them. Kate receives an offer to move to St. Louis. As a new family dynamic emerges, everyone contemplates and wonders what the future may hold.