In the season premiere, Neil deGrasse Tyson sits down with former President Bill Clinton, who was a strong advocate of science education and advancement during his two presidential terms. President Clinton opens up about his deep appreciation for science as he delves into topics including the importance of science in politics, the cosmic perspective, the Human Genome Project and Einstein. At the Cullman Hall of the Universe, Tyson continues the conversation with his comedian co-host Chuck Nice and genomics expert Juan Enriquez. Meanwhile, Bill Nye gives his take on advancing scientific progress in America, author Richard Muller joins via video call to talk about the influence of science on politics and Tyson answers fan questions about artificial intelligence.

Emmy® award-winning producer, actor, comedian and writer Larry Wilmore joins Tyson in the hot seat as the two delve into the intersection of science and comedy. At the Cullman Hall of the Universe, Tyson is joined by his co-hosts: comedian Chuck Nice and Scott Weems, author of “Ha! The Science of When We Laugh and Why.” The three discuss the physiology of laughter, the mathematics of crafting jokes and the link between humor and creativity. Adding to the discussion, author Andy Weir patches into the studio to discuss the comedy in his book “The Martian” and Bill Nye presents an improv performance to demonstrate that science can, in fact, be funny.

Neil deGrasse Tyson joins Seth MacFarlane, creator of “Family Guy” and fellow executive producer of “Cosmos: A SpaceTime Odyssey”, to discuss the role science plays in his work and personal life. In a private interview, the two take on myriad topics, including social issues in cartoons, the science of “Family Guy” and the science fiction parodies that abound in the series. Tyson is joined in the Cullman Hall of the Universe by comedian co-host Chuck Nice and astrophysicist and AMNH research associate Charles Liu, and later Bill Nye gives his take on cartoons and animation.

Neil deGrasse Tyson interviews magicians Penn and Teller and discusses the science of illusion with co-host Chuck Nice and guest Susana Martinez-Conde.

Neil deGrasse Tyson expands his cosmic perspective with actress and activist Susan Sarandon. The two discuss gender, race, perspective, marijuana and Carl Sagan.

Neil deGrasse Tyson interviews musician David Byrne and discusses creativity in the arts and sciences with co-host Maeve Higgins and guest Monica Lopez-Gonzalez.

Neil deGrasse Tyson interviews Mars One co-founder Bas Lansdorp and discusses the idea of establishing a permanent human settlement on Mars with co-host Eugene Mirman and guest Mike Massimino.

Neil deGrasse Tyson interviews David Crosby and discusses folk music and social justice with co-host Chuck Nice and guest Thomas Sugrue.

Neil deGrasse Tyson interviews physicist Brian Cox and discusses communicating science to the public with co-host Maeve Higgins and guest Jason Silva.

Neil deGrasse Tyson interviews Gina McCarthy and discusses the EPA's efforts in keeping the Earth habitable for humans with co-host Maeve Higgins and guest Andrew Revkin.

Academy Award-winner and comic Whoopi Goldberg joins Neil deGrasse Tyson.

Host Neil deGrasse Tyson interviews best-selling author Andy Weir.

Host Neil deGrasse Tyson features his interview with comedian and car enthusiast Jay Leno.

Host Neil deGrasse Tyson features his interview with iconic actor William Shatner.

Host Neil deGrasse Tyson features his interview with Secretary of Defense Ash Carter.

Host Neil deGrasse Tyson features his interview with soccer goalie Hope Solo.

Host Neil deGrasse Tyson features his interview with astronomer Jill Tarter.

Neil deGrasse Tyson features his interview with NOAA Administrator Kathryn D. Sullivan.

Host Neil deGrasse Tyson features his interview with "Game of Thrones" actor Isaac Wright.

Neil deGrasse Tyson interviews jazz icons Herbie Hancock and Wayne Shorter and discusses the art and science of jazz with his studio co-hosts.

Host Neil deGrasse Tyson features his interview with comedian Bill Maher and discusses satire in society with Maeve Higgins and Dr. Alison Dagnes.

Neil deGrasse Tyson features his interview with Lance Armstrong and discusses the science of cycling with Scott Adsit, Max Glaskin, and Arthur Caplan.

Neil deGrasse Tyson features his interview with Kareem Abdul-Jabbar and discusses the science of basketball with Chuck Nice and Charles Liu.

Neil deGrasse Tyson features his interview with Jane Goodall and discusses chimpanzee behavior with Chuck Nice and Jill Pruetz.

Neil deGrasse Tyson features his interview with Katie Couric and discusses the intersection of science and journalism with Eugene Mirman and Jeff Jarvis.

Neil deGrasse Tyson features his interview with Kevin Smith and discusses science fiction and the science of superheroes with Chuck Nice and Charles Liu.

Host Neil deGrasse Tyson features his interview with former head of DARPA Arati Prabhakar.

Neil deGrasse Tyson interviews Salman Rushdie and explores the science of storytelling with comedian Eugene Mirman and literary scholar Jonathan Gottschall.

Neil deGrasse Tyson features his interview with Mae Jemison and discusses the challenges of interstellar travel with Godfrey and Lawrence Krauss.

Neil deGrasse Tyson features his interview with Alan Alda and discusses science communication with Matt Kirshen and Heather Berlin.

Neil deGrasse Tyson features his interview with Stephen Colbert and discusses the intersection of science and comedy with Adam Conover and Sophia McClennen.

Host Neil deGrasse Tyson interviews author Margot Lee Shetterly ("Hidden Figures: The American Dream and the Untold Story of the Black Women Mathematicians Who Helped Win the Space Race") and actress Janelle Monáe, who starred in the movie.

Neil deGrasse Tyson interviews neuroscientist Sam Harris, and discusses everything from free will to religion with Godfrey and Andrew Newberg.

Neil deGrasse Tyson features his interview with puppeteer Frank Oz, then discusses puppets in pop culture and the people "behind the curtain" with Adam Conover and Charles Liu.

Neil deGrasse Tyson features his interview with surfer Kelly Slater, then discusses the science of surfing with Chuck Nice and William Finnegan.

Host Neil deGrasse Tyson features his interview with astronaut Scott Kelly.

Host Neil deGrasse Tyson interviews world-renowned physicist Stephen Hawking.

Host Neil deGrasse Tyson interviews chef Anthony Bourdain; Sasheer Zamata, Guy Crosby and Yvette d'Entremont discuss the science of food as it relates to taste, cooking and climate change; Natalia Reagan tries one of the hottest sauces in the world.

An interview with UFC commentator and podcast host Joe Rogan.

Host Neil deGrasse Tyson interviews actor Simon Helberg and co-creator Bill Prady ("The Big Bang Theory"); comic Chuck Nice, astrophysicist Charles Liu and theoretical physicist Janna Levin discuss the portrayal of scientists in pop culture.

Neil deGrasse Tyson features his tour of the remote Thule Air Base in Greenland, then tackles the science of defense with comedian co-host Chuck Nice and space security expert Laura Grego.

Neil deGrasse Tyson features his interview with former Vice President Al Gore, then discusses environmental science with Chuck Nice and Andrew Revkin.

Neil DeGrasse Tyson blows the mind of actor and musician Jack Black in a conversation about the size of our Universe.

Host Neil deGrasse Tyson features his interview with iconic reporter and former CBS news anchor, Dan Rather.

Host Neil deGrasse Tyson features his interview with “Game of Thrones” author, George R.R. Martin.

Together, host Neil deGrasse Tyson and actor and playwright Anna Deavere Smith explore the complex roles that art and science play in inspiring societal change.

Neil deGrasse Tyson and geek icon Jeff Goldblum meet for a curiosity-packed conversation.

Host Neil deGrasse Tyson analyzes humans’ hopes and fears about AI with actor James Marsden.

Host Neil deGrasse Tyson features his interview with parody songwriter Weird Al.

Neil deGrasse Tyson features his interview with crime novelist Patricia Cornwell and tackles all things forensics with Matt Kirshen and Rebecca Folkerth.

Neil deGrasse Tyson interviews Bill Nye, one of America’s most recognized science educators, to discuss the science of communication, romance and more.

Neil deGrasse Tyson features his interview with film director Darren Aronofsky, then dives into the extremes of storytelling and psychology.

Neil deGrasse Tyson and war correspondent Christiane Amanpour find order in the chaotic debate over journalistic neutrality.