The Conner family is thrown back together in a haze of blood and confusion, as prodigal son Griffin returns to his second family home - Bethune General Hospital.

Griffin's first day as Bethune's newest porter is a rocky one, while Melissa forges an unlikely connection with the sister of a patient whose life she is scrambling to save.

Brian resolves to improve his patient interaction after receiving several complaints, while Griffin forms an unlikely bond with a cantankerous war veteran. Dr. Tuttle refuses to consider Sandy’s diagnosis of a rare disease in a dancer.

When two babies die of a mysterious infection in the Paediatric ICU, Allen scrambles to find patient zero before Bethune General suffers a full-blown outbreak.

Bruno shocks everyone by making an obscure diagnosis that saves a patient’s life, and a momentous secret from his past is revealed. After being kicked by a patient, Sandy calls Melissa for help instead of Brian.

An offhand comment from Allen sends Melissa into a tailspin, while Brian desperately tries to atone for a past mistake.

When Rebecca is brought into the ER with a mysterious paralysis creeping up her body, Allen has to scramble to find out what's happening before it's too late.

Griffin starts to spin out of control after a harrowing car accident evokes a traumatic event from his past and Bruno gives Mel some vital tips on purse string suturing.

A tumultuous day at the hospital gives way to an awkward dinner with Brian’s family, leading to an astonishing revelation for Sandy.

Sandy struggles to say goodbye to Brian as her reconfigured family rally around to support her. Zoe and Griffin organize a labour stoppage after Lonnie is fired.

An explosion rips through the downstairs of Beth-H, changing lives there forever.

When an injured firefighter develops curious and frightening post-op symptoms, Mel and Jerry clash over how to proceed.

Griffin is forced to account for his actions when a patient dies while under his supervision.

Allen performs an extraordinarily rare and dangerous medical procedure, and Zoe’s mother turns up at Beth-H unexpectedly.

Exhilarated by her new romance with Cutler, Mel is uncharacteristically reckless in the operating room.

Cutler is drawn into a critical case with a husband and wife who are at odds over the treatment of her unexplained illness.

Allen works to diagnose a reclusive young woman’s illness, while Griffin begins to come apart at the seams.

Mel explores the significance of a literal and figurative broken heart, while Griffin embarks on a drug-fueled odyssey.

A clumsy attempt at addressing Griffin’s drug problem pushes him further down the spiral.

Mel does everything in her power to save a gravely wounded Sandy, while Griffin finally confronts the reality of his addiction.