With school on hiatus, the students pursue personal interests - but the break is anything but quiet. Trouble lurks as Charlie and Gina search for the missing diamonds, Farida tries to shake off her past, and Dr. Healy and Nancy appear to be on a self-destructive journey.

Half the class visits a, tent city, on the outskirts of Sudbury where they endeavour to help a host of people living in a makeshift shanty town. From a pregnant intravenous drug-user to a man stuck with porcupine quills, the students do what they can to help. Charlie finds financial relief (or so he thinks), and Melanie comes face-to-face with the man she wrongfully accused. Dr. Helvi tries to prevent Dr. Healy from descending further into a personal hell.

Charlie's unauthorized prescription to a prisoner puts both he and Farida in jeopardy, Melanie is intrigued by an inmate's cannabis cure for White Hand Syndrome; Eva and Gary have a confrontation with a racist police officer and Dr. Cardinal rekindles an old friendship, all while trying to talk Dr. Healy through a recurring nightmare.

Gary and Cameron find themselves trapped at a fly-in only camp with television fishing show icon, Sam Pisano. Charlie tries to make good on a promise to a prison inmate, while Melanie tries to patch things up with a miner she wrongly accused, and Gina learns something about Dr. Dallaire's personal history with Dr. Healy.

During a Tornado disaster simulation in an isolated campground, Dr. Helvi's patience is tested by both the students, the role playing actor's and a real casualty that turns up with unusual symptoms. Charlie and Farida help out a victim of a roadside accident, and while attending to her ex-husband who is in a coma, Nancy gets a surprise visitor.

Melanie and Gina try to help a wheelchair-bound octogenarian through a suicidal crisis. Charlie tries to make good on a promise to an inmate but gets inadvertently drawn into a financial mess. Nancy learns some unsettling news from Warren's fiancée while Gary tries to help out a junkie, inspiration strikes Cameron and Dr. Healy's isolation takes its toll.

Gary and Charlie attend an autopsy conducted by Dr. Helvi and learn some unsettling news. With Warren out of his coma, he and Nancy have a heart-to-heart and Dr. Healy nurses a shotgun victim back to health. Farida tries to help Erica find a good home for her two boys, and Gina and Eva find Charlie's missing goat.

A seemingly healthy Dr. Healy tries to get his job back and Farida tries to atone for her sins. Cameron tries to build bridges with his father and Charlie gets caught in a lie to Tara; Gary has a crisis of faith and Eva's cousin, Trevor, gets much more than he bargained for when his girlfriend Amanda gives birth.

Sent out in pairs, the students shadow an emergency medical team, do shifts in a hospital ER, attend to a street kid with frostbite, and keep a watchful eye on Mylo, a teenage cancer patient who has a steroid induced vision during a First Nations Full Moon Ceremony.

While on patrol with a law officer, Gary gets a taste of northern justice and a heaping helping of racism. Cameron and Gina discover that drug addiction isn’t just for the young. Eva and Melanie try to talk Mylo into resuming chemotherapy, and Charlie’s marital counseling session goes off the rails.

Charlie and Gary perform a snowmobile rescue of a lumberjack with severed fingers. Gina and Cameron come face to face with an elderly, over-prescribing doctor, and Farida deals with the death of a patient and close friend. Nancy suspects two monks of having AIDS.

Cameron and Gina look in on a patient with a broken leg only to discover a couple of junkies dealing drugs and running a surprising illegal enterprise. Charlie is forced to move in with his father and Farida struggles with grief, while Cameron’s secret sideline as an art forger is threatened. Nancy gets “schooled” by Helvi for jumping to conclusions.

Farida’s surprisingly poor performance assessment puts her on the faculty’s radar. Nancy deals with a former cup winning hockey enforcer who comes into the ER with signs of PTSD. Charlie steps in between Gary and a racist cop, Eva mishandles confidential information, and Gina’s animal rescue project is “outed” to Cameron.

Eva eases Amanda’s return to the Rez to meet the baby she ran out on. Melanie helps Mylo find her way back to treatment for her leukemia and Healy confronts Farida about her drug use, while Gina’s animal rescue operation is busted.

A cancer free Kyle comes through town and has Eva questioning her choices. Charlie takes the kids for the day but double books himself and drops them off with his dad - which gets him into hot water with his wife. A complaint is laid against Cameron and Gina that leads them to a new understanding of ethical medical standards.

An altercation with racist cop Sid puts Gary's med career in jeopardy. Nancy thinks up a unique idea to help her concussion patient get over his depression. A rift between Eva and Bonnie erupts at Melanie's bone marrow drive on the Rez.

Dallaire confronts Gary about his assault of a police officer. Eva and Bonnie’s acrimonious relationship is laid bare for the entire community to see. Gina’s apology to a patient goes terribly awry and Charlie gets news that may put an end to his dream of a medical career.

In the season premiere, Farida treats a child with a superficial injury, and gets a front-row seat to a custody battle. Charlie comes clean to Dallaire about the encounter between Gary and a dirty cop. Following a bone-marrow donation, Eva asks for a transfer out. Dawn arrests on Cameron’s watch, Gina is wheeled into the ER after her assault, and Nancy deals with the aftermath of a patient’s suicide.

Charlie wants to keep things as normal as possible while Tara begins chemo treatment. A judge orders Gary into reconciliation classes with a racist cop. Farida crosses the line with Erica’s ex-husband, Nick. Recovering from a bone-marrow donation, Eva ends up doing more caregiving than self-care, and Cameron checks in with Gina, who is suffering retrograde amnesia after her assault.

Mel and Gina begin their placement with the disorganized, addicted and cranky Dr. Kesler. Mylo boomerangs back into Eva’s care as Bonnie begins treatment for her hepatitis C. Farida skips therapy and chooses to unburden herself to a long-suffering Dr. Healy. Mould in Charlie’s house has him turning up with his family on his father’s doorstep moments after Eddy shows a home invader the business end of his shotgun.

Farida tries to care for a little girl while fending off her warring parents. Dr. Kesler reveals his Achilles heel to Gina. Charlie and Gary respond to a distress call at a hoarder’s apartment. Nancy receives a special delivery from Sergio from beyond the grave. Mel suspects a case of elder abuse, and Cameron makes a questionable diagnosis.

Gina and Cameron get a shock after treating a gunshot victim. Nancy receives a surprise visit and request from her eldest son, Sean. Marley’s biological grandmother shows up on Eva’s doorstep, sending Amanda and Trevor into a tailspin. Mylo learns the truth behind her father’s death.

Nancy’s finds herself at odds with Dr. Helvi over her handling of a teenage girl’s case. Farida discovers the reason behind Krista’s mysterious rash. Dr. Kesler brings Gina on a house call with disastrous consequences. Eddy finds yet another way to get into trouble with the cops – and Charlie. Cameron’s multiple missteps land him in disciplinary trouble with Dean Dallaire, and Melanie rescues an elderly patient abandoned in the ER.

Gina and Melanie find Dr. Kesler going through withdrawal, forcing Gina to step in and make a tough call. Gary’s unorthodox approach to a reconciliation session backfires. Charlie’s discovery of Eddy’s and Tara’s collusion ends up very badly for an avian dream home. Helvi’s and Nancy’s relationship reaches a breaking point. Farida lays down the law with Krista’s parents, and Melanie helps her elderly abuse patient regain some personal autonomy.

Good news about Tara’s progress is dampened by Charlie’s bad news about the house. Eva tries to deal with Marley’s grandmother while trying to protect Amanda and Trevor. Nancy’s attempt to send Sergio off into space brings her face to face with a life-and-death situation. Gina sees Dr. Kesler through rehab with some tough love. On an EMS ride-along with the dirty cop, Gary and Charlie save a life and learn the cop’s secret. Farida deals with heartbreak.

After four long years, will the students get their coveted white coats?