Ryan learns that life is much more challenging without Wilfred around.

When Wilfred comes to the conclusion Ryan is the only beneficiary of their friendship, he denies Ryan any further help.

Ryan has to deal with new problems when Wilfred becomes popular.

Ryan is forced to intervene when Wilfred becomes embattled with an unlikely foe.

Unexpected problems arise for Ryan and Wilfred after a traumatic experience.

Wilfred muddles Ryan's plan to introduce Amanda to Jenna.

A hairy situation puts Wilfred and Ryan's friendship in jeopardy.

Wilfred's nemesis returns with an offer that rocks Ryan's world.

A spontaneous road trip proves disastrous for Wilfred and Ryan.

Ryan and Wilfred make an extraordinary effort to boost Jenna's career.

Ryan attempts to discover the truth about Wilfred through self-examination.

Wilfred derails Jenna and Drew's wedding because of Ryan's jealousy.

In the second-season finale, existential questions are posed to Wilfred and Ryan.

Ryan and Wilfred search for Wilfred’s original owner.

Ryan befriends Wilfred’s enemy—the mailman.

Ryan distrusts his sister's new love interest.

Ryan takes Wilfred to a dog training class in the hopes of winning over a girl.

Ryan finds a roommate with Wilfred's help.

Wilfred forces Ryan to collaborate on a birthday gift for Jenna.

Wilfred leads Ryan on a crime-fighting caper.

Ryan tries progressive psychotherapy to better understand a past trauma.

Wilfred crashes Christmas and pits Ryan against his family.

A struggle emerges between Ryan, Wilfred and an old friend.

Wilfred pursues a forbidden love.

Ryan is put in danger as Wilfred pursues the path to valor.

Season 3 ends with Jenna forbidding Ryan from seeing Wilfred when he needs him most.

When Ryan's reality is upended, he gets a second chance to make things right.

Disaster strikes when Ryan and Wilfred get an unwanted guest on their camping trip.

Ryan and Wilfred take sides in Kristen's custody battle.

Ryan subjects Wilfred to a scientific study with unsettling results.

Ryan and Wilfred have drastically different accounts of the same disturbing incident.

While trying to uncover who his father was paying off, Ryan runs into Bruce, only to be a pawn in his next game.

Ryan helps his mother adjust to her new life as Wilfred deals with a new nemesis.

Wilfred convinces Ryan to withhold sensitive information from Jenna.

Ryan fears a future without Wilfred, as his battle with cancer becomes more severe. Drew returns from Wisconsin.

Ryan finally learns his truths about Wilfred and his life.