Lele is anxious to see Alice again after her declaration at the airport, but a letter sent by her seems to cast shadows on the future of their relationship. What will happen?

Lele goes to the airport for Alice's arrival, but in her place arrives a woman who Alice met in Africa and to whom she gave the ticket. There is still a wait for the two lovers, but what will happen when the time comes?

Lele decides to give Alice the ring she had bought some time before, but it seems to have disappeared into thin air. Meanwhile, the story between Cettina and Giacinto seems definitively over.

Lele's birthday but the whole family pretends to forget about it to throw him a party. Meanwhile, the doctor's relationship with Alice is being kept secret, but how long will they be able to live in hiding?

Libero would like Lele to marry Alice, but his son does not feel ready yet. Er Pasticca, a friend of Alberto's, asks him to deliver some pills, but these end up in Annuccia's hands.

Alice has organized a romantic weekend with Lele, but the latter has to go to a conference in Turin. Among her colleagues there will also be an old friend of Lele of whom Alice is terribly jealous.

Cettina asks Giacinto to meet to clarify their situation, but the latter does not appear as he is the victim of a stabbing. Cettina can't know it, and imagines that the ex didn't show up deliberately.

While at Alice's house, Lele learns that her fiancée has been receiving phone calls for several weeks from a manic admirer, who doesn't seem to want to stop there.

Libero participates in a competition to win one evening at dinner with a singer, introducing himself as They Killed Spider-Man. The grandfather takes home the victory: Max Pezzali arrives at the Martini house.

While the Martini are on the radio, Lele receives a phone call announcing that Alberto has had a car accident. Everyone rushes to the hospital and discovers a very different reality.

Alice spends more and more time at Casa Martini. Alberto feels responsible for the accident that left his friend Adriano disabled, but thanks to his uncle's help he will find the strength to go and see him in the hospital.

Lele and Alice have decided to get married and are looking for a place for their honeymoon together. Everyone helps them find it, but everyone has her own opinion and in the end they decide to go it alone.

While preparations are underway for Lele and Alice's wedding, the latter is assailed by doubts. Lele finds a letter in which the woman says she is confused and wants to think away from him.

A group of girls dressed as odalisques arrive at Lele's bachelor party, including one in particular who is very close to Lele. Alice catches him in the act, but are we sure she saw us right?

The preparations for the wedding seem to never end. The small village where Alice spent her holidays as a child was chosen for the wedding ceremony. But there is no shortage of setbacks.

Lele and Alice are finally married, but while they are leaving for their honeymoon, the woman has a miscarriage, not even knowing she is pregnant. Plans change dramatically.

Maria and Reby come up with a really good idea: to have their friends play in the garage! Will they be able to get Lele's permission? Giacinto thinks of leaving his job as a security guard and opening a shop. Will Cettina allow it?

"Pisticca" apologizes to Adriano, but will he be able to make up for it? To escape Carmelo, a very insistent suitor, Enrica takes refuge in the Martini house. What will Lele and Alice come up with to stay alone for a while?

Alice feels bad all the time and already a few people tell her that the symptoms are all there and that she could be pregnant. Instead, Lele fears that it is something serious.

Alice does the ultrasound and discovers that she is expecting twins. Lele and Alice go home to announce the news to the others, when a phone call arrives letting Nonno Libero know that his friend Fausto is in the hospital.

Nonno Libero packs his suitcase and leaves home due to the constant quarrels of his two children, who find him in a rest home. Until he learns that he has been appointed condominium administrator.

Nilde wants Lele to enter the delivery room, but the next day Lele wakes up late and arrives at the hospital when her sister has already given birth, by surprise, to a black baby.

Alice and Lele announce the sex of the unborn children to the family: they will be a boy and a girl, but the happiness is not shared by the whole family because Annuccia becomes jealous.

Alice is very anxious about the arrival of the twins, and fills the family with advice and reading manuals on birth. Not to mention the contractions that terrify her and force the couple to rush to the hospital every night.

Alice tries to help Maria who is facing a particular moment in her life: Roberto has asked her to make love with him, but the girl doesn't feel ready for such an important step, even if telling her is difficult.

A great job opportunity for Alice is ruined when contractions begin. Meanwhile Lele is in the hospital where Giorgi died from a post-operative rejection... Will he be able to arrive in time for the birth of the twins?

Lele leaves for Australia while Alice, who will soon join her husband, is in Brazil. Maria meets Guido at the University, a brilliant doctor who is looking for a house and will be hired by the new director at the Local Health Authority.

Maria is very fascinated by Guido, but it seems that the doctor is not interested in her at all. Meanwhile Ciccio, after a prank that risked ending in tragedy, tries to escape from Lele in Australia.

Enrica notices the growing understanding between Maria and Guido and puts a "flea in the ear" of Nonno Libero who begins to worry. Meanwhile, everyone begins to discover that Alberto has not even given an exam at the University.

Nonno Libero does not want anything to happen between Guido and Maria and does everything to keep them away. Meanwhile Alberto is depressed and sleeps in the garage to be alone. He will need the help of the family to get him out of the dark evil.

Cettina sets out to look for Giacinto, discovering a bitter truth. Maria, due to a painful episode, no longer wants to take medical tests. Will Guido be able to convince her otherwise?

Nilde is forced to close the restaurant due to poisoning and notices that Guido is the one who signed the complaint. Alberto, by improvising a nighttime radio episode, manages to get hired on a permanent basis.

A new nutritionist, Carlotta, arrives at the ASL. With her obsessive and detached behavior it is not possible to win her sympathy, and misunderstandings and disagreements arise between her and Guido. Until something brings them back together.

Guido tries to make friends with Carlotta, but the obstacle to overcome is the girl's phobia of physical contact, a difficult difficulty to overcome. Meanwhile, Maria is increasingly jealous of Guido.

Nonno Libero meets Antoinette, the nanny of one of Annuccia's classmates; the child is strangely too calm and Antoinette doesn't understand why, so Nonno Libero invites her to take him to the ASL, to have him examined by Guido.

A mysterious statue found in the garden divides the family. Guido tries to help Carlotta solve her problem, but the situation soon escalates to near disaster.

Carlotta confesses to Guido that she is in love with him, sending him into a crisis because he cannot understand his feelings for Maria. The birthday dinner with the latter, however, skips due to a hiccup.

Maria is happy to have met Gianluca, a charming lawyer, who courts her like a real princess. Meanwhile, some kids enter Ciccio's school at night and break the pipes to skip questions and homework.

Gianluca surprises Maria by taking her to lunch on a boat on the Tiber, which carries a flag with Maria written on it. Meanwhile, Guido has gotten together with Carlotta, and everything seems to be going well... or not?

Carlotta suggests that Guido move in together, the doctor accepts. Meanwhile Maria, having broken off the story with Gianluca, has started working as a volunteer in a recovery center for drug addicts.

Maria is preparing for an exam and is very nervous and Nonno Libero thinks it is Gianluca's fault. Guido and Carlotta continue their story, even if the failed cohabitation puts the relationship to the test.

Nonno Libero picks up the news on the news that a young blonde student has been arrested in Fiumicino together with Gianluca for drug dealing. Thinking it's Maria, he feels bad and suffers a heart attack.

Meanwhile, Guido has problems with Carlotta, tired of seeing her boyfriend totally taken by the Martini family. Maria sees Gianluca in front of her house who tells her he wants to escape to avoid trial.

Guido and Carlotta are increasingly in crisis and during a dinner they argue again. Guido goes to a friend's house who introduces him to two girls and the following morning, the doctor wakes up drunk next to one of the two.

Maria is angry with Guido and disappointed because he betrayed Carlotta. A course on self-esteem is held at the ASL and thanks to it the doctors are able to bring out their problems, especially Carlotta.

Guido and Maria go to get Annuccia from the biopark, but the little girl gets lost. Because of this, Guido does not show up for the appointment with Carlotta, but in the meantime Maria and the doctor finally kiss.

After the kiss at the biopark, Guido understands that he has feelings for Maria but she would like him to leave Carlotta first who, in the meantime, seems increasingly tied to Marcello and not just for work.

Maria is tired of waiting for Guido and decides to go out and have fun with Reby. During a night outing she is stopped by the police and her car is withdrawn. Who's gonna get her out of that mess?

Maria and Guido go to the beach to be alone and when they return home, covered in sand, Libero understands that the two have spent the afternoon together. However, due to an error, Guido is suspended from the ASL.

Maria asks Nonno Libero not to tell anyone about her affair with Guido, but he realizes that in reality everyone already knew. Meanwhile, Guido makes home visits and the patients show up at the Martini house because they only want him.

The story between Guido and Maria falls apart due to a misunderstanding. Even grandfather Libero is furious with the boy, he can't understand that in reality it's not his fault. Guido then decides to make a video to explain everything.

Having lost all hope of getting Maria back, Guido asks for an immediate transfer to Milan and outside the ASL he says goodbye to Marcello and Carlotta. During the journey to the church, Maria realizes that she wants Guido and she runs to the station.

There is a lot of news in the Martini house: Maria and Guido have been engaged for two years and Guido goes back and forth between Rome and Milan, Ciccio still plays rugby and is engaged to an English girl named Emma and…

Nonno Libero is summoned to school because Annuccia has done a decidedly strange essay on the family. Maria rents a house for her and Guido, but discovers that, for now, he is forced to stay in Milan.

Meanwhile, Guido is sad because he has to stay another two years in Milan and doesn't know how to tell Maria, who in the meantime is doing an internship at the ASL. On the way to Milan he has an accident.

Maria misses Guido very much and is thinking of continuing the university in Milan at least until she graduates. Guido meanwhile is trying in every way to get transferred, but it seems that there is no hope.

Cettina and Torello's house is now completed, but Cettina will find some nasty surprises. Maria and Guido have decided to move in together and to keep them from going far Cettina will find an unexpected solution.

The family members decide to give Guido and Maria a whirlpool and a Bohemian crystal chandelier, but the boys get angry because they would like to be the ones to furnish the house. The first quarrels arise.

Between friends and family, at Guido and Maria's house you can't find a moment of peace, and this certainly doesn't do the couple any good. Nonno Libero, on the other hand, due to a series of misunderstandings, thinks that Ciccio is on drugs.

Grandpa Nicola is back in style, but the reality is very different from what he wants to make it seem. He invites Maria on a cruise and she, who initially refuses, finally understands that her grandfather has only her family affection left.

Between friends and family, at Guido and Maria's house you can't find a moment of peace, and this certainly doesn't do the couple any good. Nonno Libero, on the other hand, due to a series of misunderstandings, thinks that Ciccio is on drugs.

Cettina asks Torello to let her nephew Rosalbo join the company, but one night they hear him plotting against them on the phone. The two decide to make life impossible.

Cettina doesn't know how to tell Torello that in reality she isn't pregnant because he is showering her with attention, organizing everything for the future baby. During an ultrasound, she steals footage showing triplets to play along.

Libero is worried about Olindo, an old friend of his who has been missing for days. He learns that he is in a hospice he can neither talk to him nor know how he is. Libero then asks Guido to make an inspection.

Maria has returned from the cruise and Guido immediately fills her with affection, so much so that the two are caught by the entire Martini family immersed in the whirlpool. Meanwhile, Cettina has a decidedly "horror" experience.

Guido is anxious because he has to present the project for the family hospital, but Maria forgets the interviews with the ASL. But the troubles aren't over: the scooter doesn't work, it's a race against time.

Reby tells the Martinis that she is getting married to a Japanese designer she met the week before. Maria is not convinced, knowing the fast falling in love with her friend, but this time it seems serious.

Guido finds a pregnancy test, actually belonging to Reby and, frightened by something he feels is bigger than him, he runs away and leaves himself a note for Maria. The girl, with no news from her for two days, is heartbroken.

A man very similar to grandfather Libero has been wandering around the Martini house for a few days and for grandfather trouble begins: everyone begins to think that he is seriously getting old and does not remember things.

After a check-up recommended by Enrica, grandfather Libero learned that his values ​​are not good and that open heart surgery may be necessary.

Libero writes a letter and delivers it to Enrica with the task of sending it to Lele in case he dies, then both go to the town hall to sign the marriage papers and ask to get married as soon as possible.

The ASL risks closing and all the doctors organize a protest sit-in, which will prove to be useless. Guido, on the other hand, decides to make a request to return to Milan, given that staying in Rome no longer makes sense for him.

While the ASL is being dismantled, the doctors decide to carry out all the visits on the list for free. Meanwhile Guido is nervous and has an argument with Maria. Furthermore, he will be responsible for definitively closing the ASL.

Franco decides to take Maria to a farmhouse, but the same evening the girl, after reading a note from Guido, realizes she is confused and luckily the only thing she is sure of is that she doesn't love Franco.

Guido is looking for funding for the family hospital and decides to organize a heart game to raise funds and at the same time proposes a donation to the bank.

After spending the night with Guido, Maria runs away and confides in Reby, telling her friend what happened the night before. But she also tells her that she's confused that she doesn't know what she's feeling right now.

Guido and Maria are back together and are stronger and happier than before, but he wishes Maria would not leave for Nigeria. He also has a really important proposal in store.

After three years of absence, Lele returns to the Martini house, finding a situation that is not a little indifferent. Thanks to the help of Nonno Libero, Lele will finally be able to become a full-fledged family man again.

Lele moved to Paris, together with Alice and the twins. Guido is still in Africa with Maria. Meanwhile, Dr. Emilio Villari arrives at the Martini house in Rome to set up a new private clinic.

Alberto returns to live at the Martini house, and the family understands that his relationship is over. Cettina continues to be overprotective of her son Eros, to the point of not being able to bear the idea of sending him to kindergarten.

The Martini family meets the new Indian neighbor. Ciccio and Annuccia, after the first reticence, make friends with their grandchildren. Meanwhile, Poggiofiorito is becoming an independent municipality, and it's time for grandfather Libero to apply.

Nonno Libero is engaged in the electoral campaign against the lawyer Ulmi, who has Nonna Enrica among his supporters. The propaganda takes place with no holds barred, and culminates in a televised face-to-face.

Nonno Libero bears less and less the confusion of customers outside the Indian restaurant, and would like to close it. All the women rebel because they have started attending a yoga class organized by Kabir.

Alberto receives a letter from someone who makes an appointment with him at the mall and the boy believes it is his ex... Cettina is increasingly taken by Kabir and confesses to grandfather Libero that she can't help but think about it.

Alberto tells Ciccio that he has seen Maria, but his cousin doesn't believe him. Nonno Libero and Torello also tell the same story. The decisive confirmation will be in Annuccia's essay, which will see her sister among the spectators.

Maria goes to find Annuccia at night, leaves her a drawing and runs away, but the little girl wakes up and calls her grandparents. Libero chases after the girl, who finally no longer has to hide. But she looks very changed.

Cettina lives with Torello separately at home. Meanwhile Alberto and Ciccio go to see Maria, but the girl shows that she wants to liquidate them quickly. She confesses that she wants to forget the two years spent in Africa.

Nonno Libero goes to see Maria and tries to convince her to go home, but the girl still doesn't feel like it. But an unexpected event will make her change her mind.

After being called back by his fiancée's father, Emilio has to return to Turin for good. During a dinner with Sarita, the two believe they will never see each other again and so, from a kiss, passion is unleashed.

Emilio declares his love for Sarita, but the girl fears that they will end up hurting each other. Meanwhile, Torellhonor seems to be bankrupt, while Maria decides to offer herself as a waitress at an Indian restaurant.

Torellhonor is on the verge of bankruptcy. Meanwhile Sarita and Emilio, after having convinced an Indian couple not to practice abortion, decide to open a counseling center for non-EU women.

Cettina is forced to remove Eros from the expensive private kindergarten and take him to the municipality one. Alberto discovers that his father has cancer and he has only a few months left to live.

Alberto discovers that chemotherapy has not had the desired effect on his father. However, the boy decides to indulge him in the desire to live peacefully the time that remains to him. Cettina asks the Martinis for hospitality.

Big party at Indian restaurant. Ciccio, Annuccia, Saju, Sarita and Maria offer themselves as dancers and enliven the evening. Maria is elected "Queen of the party" and finally confides her secret to Sarita.

Ciccio and Miranda decide to flee and take refuge in a farmhouse in the countryside, owned by the parents of a mutual friend of theirs. Everyone is worried, but thanks to the intuition of little Eros, Nonno Libero knows where to look.

At the outpatient clinic they are all gathered to wait for the announcement of who will be fired, but everyone is amazed to read that Emilio has resigned to save his colleagues.

Sarita accepts Emilio's marriage proposal, but Indian tradition requires the groom to go to the bride with his parents and ask her family for her hand. Libero and Enrica offer to accompany him.

Sarita tries to convince Kabir to accept Emilio, but he is against it because according to his mentality it is very important to respect the traditions. The girl then decides to leave her house and goes to stay with the Martinis.

Sarita and Emilio have to keep the intrusiveness of their respective families at bay: Enrica would like to organize a big wedding, while Kabir a traditional Indian party.

To save the clinic, Emilio proposes to buy it with colleagues and patients, all becoming owners of a small share. Meanwhile, stag/hen parties are organized for future spouses.

Ravi's arrival at the Indian restaurant creates confusion, also because Kabir doesn't have the courage to reveal to him that his niece will soon marry Emilio. As if that weren't enough, the young man shows up at Sarita's clinic.

Maria falls ill with mumps and can no longer discuss the thesis to prevent the girl from waiting another three months, since she can't wait to go back to Africa to see Guido. To resolve the situation, the family makes a plan.

Ravi gives the girl a letter from his father, written 25 years earlier, in which he claims to have promised his daughter in marriage to repay him for a theft. She refuses to marry him, so Ravi orders her to pay off her debt.

Sarita has decided to marry Ravi. Maria lets slip with Emilio the reason why the young Indian left him. The latter goes to the hotel to Ravi and assaults him. Maria finally manages to defend the thesis and graduate with 110.

Many returns to Casa Martini: Guido has returned to his experience in Africa, Lele returns with the twins. Absent instead Cettina and her family: the former housekeeper Martini has apparently disappeared in a shipwreck.

A nasty surprise awaits Guido and Maria: in fact, the two discover that the tenant of their apartment does not want to return the keys. During a chat, Nonno Libero reveals to Lele that he feels the weight of her old age.

Grandpa Libero left, it's up to Lele to look after the whole family. Elena and Bobò are anxious about their first day of school. Annuccia continues to behave rather arrogantly towards her younger brothers.

Maria is entrusted with the case of a little girl hospitalized for some stomach pains probably due to the absence of her grandfather, who left on a long journey. Maria discovers that the truth is much more painful.

Fanny and Maria become friends, but Maria is jealous because she fears that Fanny will flirt with Guido. She does not imagine that the young colleague is interested in another member of her family: her father.

Maria's pregnancy proceeds and cravings also arrive. Meanwhile, a child neuropsychiatry department will also be opened at the clinic, which is precisely the specialization of the young doctor.

Libero and Enrica return from Puglia for the Christmas holidays. Meanwhile Guido is refractory to the idea of starting a relationship with his newly found mother. Fanny discovers toxic waste dumped in a river.

Guido and Ave have a tough confrontation and the latter makes the fact that she hasn't been there in times of need increasingly weigh on her. Giulio wins the trio in the lottery and an unexpected snow in Poggiofiorito decorates Christmas day.

Maria prepares an exclusive evening for her and Guido, who is forced to stand her up. She feels a bit excluded from Guido's life since she is expecting a baby, and is convinced that he no longer likes him since he has a big bump.

As the last months of pregnancy approach for Maria, Lele feels that becoming a grandfather will be a new adventure, completely different from being a father. All the more reason because Mary's waters break early!

Nonno Libero returns to Rome to meet little Paola. Lele tries to convince Fanny not to continue the relationship, but she is really in love with her.

Giulio convinces Nonno Libero to participate in a new program, Cambio Nonno. Libero accepts and finds himself with a new family, moreover, from Lazio. As a result, that family's grandfather moves in with the Martinis.

The twins notice the silhouette of a woman behind the window of the Torello house and believe that it is the ghost of Cettina. Nonna Enrica, in this regard, organizes a séance to evoke her together with her friends.

A friend of Annuccia surprises Fanny and Lele. Annuccia, after finding out from her friend, doesn't accept her father's new girlfriend, unlike the family who are still a bit confused.

A colleague confesses to Lele that he is in love with Fanny. Lele, embarrassed, does not reveal that he is having an affair with her girlfriend. Meanwhile, Ave tells Guido that her sister did not take well the news of having a brother.

The twins convince Bianca and Lele to go to the Aqua Park, where they hope to make them fall in love. Fanny decides to follow them to get to know the twins well, but they really don't want to know.

Fanny decides to introduce Lele to her family. She has received permission from the Martinis to move into their house, because the maid Melina is unable to look after the child alone.

Bianca receives from the Vatican the task of preparing a chocolate sculpture, but the twins reduce it to crumbs. Lele helps Bianca and, after working all night, the two kiss.

Lele discovers that Fanny's analyzes have been switched and therefore the girl is not pregnant. The two decide to break up and now Lele can stay with Bianca, but the latter is about to return to the Netherlands.

The Martini family is summoned by the police because an American woman asks about them. The Martinis discover that the woman is actually Cettina, even if she seems to remember nothing of her past.

Lele tries, in vain, to get closer to Bianca, hurt by how she was treated by the doctor. She has felt seduced and abandoned by Fanny's pregnancy, and it is hard to forgive.

Maria believes that Guido is cheating on her with Albina, without knowing that she is his sister. Lele makes one last attempt to win Bianca back, but it's too late: she, the latter has to leave for the Netherlands.

The Martini family organizes a surprise birthday for Lele, desperate because he thinks of the woman he loves. Ciccio learns that Tracy has returned to Rome. She can't resist: he goes to see her at the stables!

Guido confesses the betrayal to his wife, who packs her bags and goes to live alone with her daughter, making Guido desperate. Ciccio understands that he is in love with Tracy. Meanwhile Lele goes to London and declares her love for Bianca.

Guido tries to win Maria back, but the girl, when she seems to have forgiven him, sends him a separation request. Lele intends to stay in Rome forever and announces it to the family, who are enthusiastic about it.

The double wedding of Nonno Libero and Ciccio is upon us and preparations are underway. Maria and Guido have to meet the lawyer for a preliminary interview, to talk about the separation. But will it be the right choice?

Three years have passed since Guido's death, and the time has come for Maria to start over, even sentimentally. Meanwhile Lele asks Bianca to take the plunge, but she discovers that she is still married to her ex-husband.

Bianca is determined to divorce in order to marry Lele, who in the meantime has met an old acquaintance of his, Virginia, in the context of research to cure a rare disease. In addition, problems ahead for Annuccia.

Bianca finds herself fighting on two fronts: seeking information about her ex-husband, and jealousy for Virginia, which grows despite Lele's reassurances. For Maria it's time for an attractive job offer.

Marco announces on the news that the mozzarella of Puglia d.o.p. di Nonna Enrica are produced with different milk and not with buffalo milk. Start the war!

Lele holds a lesson on the environment at Annuccia's school and is very popular among her daughter's classmates. In the meantime, Bianca's ex-husband, to put a spanner in her wheels, is determined to win over her little Inge with all the necessary little tricks.

A bolt from the blue strikes Bianca: the chocolate shop has been put up for sale. Furious and scared about the future, she finds herself weighing up her ex-husband Gus's offer. Meanwhile, grandmother Enrica plots to bring Maria and Marco closer.

The little ones of the Martini house are victims of bullying at school. When Lele and Bianca discover the situation, they convince the children to report what has happened to the teacher. Bobò will show all the necessary courage.

Lele's jealousy leads him to follow Bianca, who has left for the countryside with Gus and the children. Meanwhile, Maria helps Marco unmask an illegal gambling den.

Maria, with the help of all her family, takes care of her little Palù and goes back to work in the clinic. Nonno Libero, having left for America, entrusts the task of running the company of Apulian food products to Nonna Enrica.

A hot air balloon ride offered by Gus turns into a cauldron of tensions. Lele joins them as soon as she can, just in time to see the engagement ring she gave Bianca fall down.

Grandma Enrica returns from the United States with a surprise that leaves everyone stunned: in fact, she has taken a homeless person under her protective wing who leaves the whole family stunned.

The Martini Christmas dinner is, as always, a sea port. And this year, on the day when everyone is kinder, Lele will give Gus a break.

Lele, due to the presentation of the research for the drug he is working on, spends more and more time with his colleague Virginia. Virginia's ex-boyfriend, increasingly jealous, continues to harass the doctor.

Maria feels guilty for not having dedicated enough time to Marco lately. But when she shows up at her house by surprise, she'll be the one to be left speechless.

For Ciccio it's time for a hard discovery to accept: Tracy doesn't want to get pregnant because of the competitions to be achieved. Meanwhile, Maria does not believe Marco's explanations.

Inge is willing to do anything to spend her father's birthday at the farmhouse with him. Despite Bianca's remonstrances, she implements an infallible plan, which will cause many problems, even for Lele.

Ave receives an anonymous letter from a woman, in which she learns that Guido's heart has been transplanted into her son's body. Meanwhile, Giulio meets Magalli, to whom he would like to propose a TV format.

Both the clinic and the company that was involved in the production of the drug are denounced by the brother of the patient being treated. Meanwhile Marco and Maria discover that they really like each other.

An inspector from the ministry comes to check the clinic after Virginia chooses to administer an as-yet-unlicensed drug. Marco receives a sudden phone call and discovers that he will have to leave for Venice.

Between Maria and Marco everything goes swimmingly, and passion explodes. Meanwhile, Bianca discovers the truth about her divorce with Gus at a crucial moment in their relationship.

Lele is determined to take over the reins of his love life, making it clear to Virginia that there is nothing between them and declaring in front of his children that he will do anything to get back Bianca, the only woman he loves.

The discovery of a pregnancy deeply disturbs Bianca, who decides to leave. Virginia will look for her to explain the reality of the facts.

Like the rampant baron, Inge decides to run away from home, just on the day when Bianca is busy preparing a birthday cake for Maria. The searches begin.

The searches continue and finally Gus finds his daughter at the farmhouse, proposing to leave with him for Los Angeles. Lele and Bianca at the first ultrasound of the baby discover that Ciccio and Tracy are also pregnant.

At the Martini house, preparations are in full swing for the wedding of Lele and Bianca. Little Palù is given the task of bringing photos of her parents to school and Maria helps her daughter overcome the pain of Guido's disappearance.

The big day has arrived, and everyone is ready to reach Ovindoli where Lele and Bianca's wedding will take place. But as always in the Martini family, the unexpected is just around the corner. Will they make it?

Nonno Libero has finally returned to Poggio Fiorito. Immediately, Marco and Maria announce their marriage, which will take place in two weeks. For the occasion, the grandfather has a special surprise in store: to hire Al Bano!

The proposal to buy the Aurora clinic forces Lele to tell the truth about the house they are about to take from him. The Martini family, informed, takes action.

For the Martinis the situation is critical. Really risking losing the house, grandfather Libero goes on the trail of the builder who cheated them.

For grandfather Libero, the loss of the house is such a serious threat that it even interferes with his own health. After his reluctance to sell used items at the neighborhood market, the family convinces him that everything is fine.

Lele finds herself clandestinely treating an old patient of hers. With great risk, she decides to start visiting clandestinely those patients who cannot adjust to the too high prices of the Clinic.

Annuccia starts the part-time job of pony express in order not to ask her father Lele for money for the international class trip. She finds herself in a seedy neighborhood when thugs harass her.

Relations between Bianca and her mother worsen under the sorry eyes of Inge, who is really fond of her grandmother. Meanwhile Marco lies to Maria about the new assignment he has received.

As if they weren't troubled enough already, the Martinis have to re-roof their house. It's not exactly the right time economically, and the family is really worried.

Lele and Bianca discuss it and believe it is necessary to fire the gardener, who has been tending the garden of the villa for years, but Melina, overhearing the conversation, believes that she will be fired. So she immediately gets busy.

Marco returns to Rome and Maria picks him up at the airport. Unexpectedly, his colleague Antonia is also with him. Lying once again to her girlfriend, Marco manages to get away with a lie, but Maria begins to suspect.

Lele and Bianca discuss the future of the Martini house and therefore decide to look for new accommodation. However, the news is not well received by the children, who decide to occupy the house, without the knowledge of the whole family.

Marco gives Maria the engagement ring, and promises her that they will get married immediately after her last departure for Brussels. Meanwhile at Villa Aurora, Lele and Guenda seem to get closer, after she shows the human side of her.

Maria has no idea where Marco is and therefore takes it upon herself to authorize the operation on little Jonathan. She discovers the bitter truth: Marco lied to her, continuing to shoot documentaries in war zones.

Marco returns to Rome and Maria is waiting for him at the airport, but only to inform him that it is definitely over between them. Both back home, the situation seems to improve: but how long will it last?

Between Marco and Maria it seems to get worse and worse, so much so that he goes home early in the morning to make the children believe that he still lives with them. Nonno Libero notices the situation and promises to help him.

Inge, seeing her father increasingly sad, decides to arrange a meeting with the estranged mother of a schoolmate of hers. However, the appointment falls apart and the woman suffers from anaphylactic shock.

Maria seems more than ever willing to embark on a relationship with Roberto, however continuing to hide everything from Marco, who begins to suspect.

The story between Maria and Roberto seems to continue at its best, but when she discovers that Palù has bitten her friend, showing an aggressive attitude that had never been shown before, she understands that the little girl is suffering.

Marco is in danger of losing custody of Jonathan, but Maria offers to help him. The situation becomes more complicated in this way, because now Marco and Maria are forced to organize a fake wedding.

Marco and Maria with the help of the family manage to convince the assistant. Everything could be resolved, were it not for the fact that Micol threatens them: if the wedding doesn't take place, she will do everything to get the baby back.

Marco and Maria announce to their children that when the two return from the camp organized by the school, each will go his own way. At this point Maria can devote herself to Roberto and introduce him to the family.

While Maria is in the car to join her daughter at the campsite, her car breaks down. So she decides to call Roberto, but just at that moment Marco arrives and offers to accompany her.

Lele helps Maria clear her head and the young woman understands that her heart actually beats for Marco. Unfortunately Roberto's father is on the brink of bankruptcy and Maria doesn't feel like leaving him now.

Antonia does everything to distance the journalist from his ex-girlfriend to the point of making Maria believe that, in addition to moving to New York City, Marco is going to live there with her.

Everything seems to turn out for the best: Lele manages to buy back the house with the money he got in Paris thanks to Bianca's broadcast, while Maria, after having clarified her doubts, will go back to Marco. And Roberto?

As they are about to cut off electricity and gas at the Martini house, the family decides to leave before everything ends before their eyes. But there's still time to plan a surprise wedding for Maria.

Maria and Marco are busy preparing for the wedding of his younger sister, Sara, who is arriving from America. Grandfather Libero and Enrica are also waiting for the arrival of Lorenzo, surgeon and Libero's nephew.

Sara reveals to her brother Marco that she will no longer run for competitive purposes. By inventing a lie, she covers up the truth: Sara, in fact, also suffers from heart problems. Meanwhile, her wedding presents are sent back.

For Elena and Bobò it is the first day of high school and both are prey to the first anxieties and fears. Elena decides to skip school and go to the beach with Tommy, who she immediately fell in love with. Bobò will cover it.

Giada's arrival at the Martini house is like a bolt from the blue. The only one she spoke to for a while was Sara, who would like to help the girl she rescued on the street in every way.

Sara begins to manage the new bar in front of the Martini house. On the morning of the opening, however, a young manager of a chain of aperitifs, Stefano, shows up in the room and would like to take over the place.

Sara suffers a bar robbery by the two guys who blackmail Giada. Lorenzo finds Sara passed out on the ground and calls an ambulance. In the clinic, the young woman wakes up and learns from Lorenzo that she should do a CT scan.

Grandpa Libero and Grandma Enrica are grappling with the vaccine for Palù and Jonathan in the clinic. Stefano takes Sara to her country estate and here the two get very close.

Lorenzo is running with Sara who, due to overdoing it, ends up feeling bad, given her heart problems. Grandma Enrica and Ave convince grandpa Libero to go on a diet, practicing an oriental gymnastics course.

After the night spent together, Lorenzo tells Sara that the situation is difficult and they can't be together. However, the two continue to find themselves ever closer, even when, each on his own, they decide to go to the cinema.

Sara and Stefano spend a wonderful day paragliding. Everything gets blurred when Sara reveals to him that, due to a heart defect, he could die at any moment.

The news comes out in a newspaper that between Marco and a certain Fiamma, an athlete and Sara's acquaintance, there is something tender. Maria finds out, but her husband assures her that it's just a journalistic invention. Will it be true?

Stefano and Sara spend the night together, but nothing happens between the two. The young man, however, takes the wrong door and finds himself in the living room of the Martini house, with the whole family. He finally gets to know them!

Marco and Maria discover where Daniel, Giada's little brother, is. His parents accept on one condition: Daniel must not know that Giada is his sister, just as he does not know that he was adopted.

Thanks to Maria's help, Giada manages to meet her brother Daniel. Between the two she is immediately understood, even if the little one fails to recognize her sister. Lorenzo, on the other hand, is very agitated about the operation he has to carry out.

Lorenzo and Veronica continue to meet secretly in the hotel. This is where Sara arrives, warning them that Fabio is on the way. In order not to arouse suspicion, Sara kisses Lorenzo and the two pretend to be engaged.

Sara and Stefano take Marco home, but the latter doesn't remember anything and has also lost his wedding ring. For this, her sister and her boyfriend decide to investigate. Tommy draws a mural dedicating it to Giada.

Fiamma is forced to reveal the truth, saying that nothing happened between her and Marco, he was drunk and kept repeating Maria's name. The two, therefore, make peace… for now.

Giada and Tommy decide to flee and get away from everyone. Maria and Marco, having discovered everything, decide to go and look for them with the help of Lorenzo and Veronica.

Lorenzo takes his wife to the mountains, on the Majella, to spend time together. But, during the vacation, Lorenzo will be forced to reveal to Veronica about the night spent with Sara.

Maria fails to tell Marco that she is pregnant, but the situation becomes more and more exasperating until the girl is forced to spill the beans.

Lorenzo remained in Poggiofiorito to assist his uncle, who faked a broken leg hoping that something would arise between him and Sara. One night, however, the young man dreams of being in a place and, with him.

Lorenzo and Sara have finally decided to force fate and get together. For this, the young man decides to leave for America and reveal everything to his wife.

Stefano takes Sara to the clinic and here Oscar tells her that her heart can no longer hold up and the only solution is to immediately go to hospital and undergo surgery. She decides not to say anything to Lorenzo.

Lorenzo decides to speak to Dr. Savino himself, but he is hiding behind professional secrecy. The last beach remains Oscar, from which he manages to discover the truth and the disease Sara suffers from.

A little girl finds Sara on the beach, unconscious. With the girl's cell phone, she calls Lorenzo, who immediately runs to her and, after reviving her, takes her to Villa Aurora.

While grandfather Libero, grandmother Enrica and Ave rely on prayers to ensure that Sara recovers after the operation, Lorenzo finds a television on which he can see a video recorded by the girl before the operation.

While the entire Martini family is on holiday in Puglia, a mysterious man leaves an envelope addressed to Elena, Lele's deceased first wife, in the mailbox of the villa in Poggio Fiorito.

Valerio, Elena's former piano teacher, tries to get to know Anna with the excuse of a rap concert and seems too interested in the affairs of the Martini house. Meanwhile, Sara, without consulting Lorenzo, signs the compromise for the purchase of a villa.

Lorenzo learns that the tendon in his hand is torn and blames Sara for what happened. The woman, mortified, decides to take a walk on the beach. There, by chance, she comes across a party where, between one beer and another, she meets Andrea. Completely drunk, the two end up in bed together.

Sara and Enrica decide to track down Dr. Williams who could operate on Lorenzo's hand, but the doctor is on vacation and refuses to work. Among the doctor's plans is to visit Rome by carriage, but a strike prevents him from doing so. So Sara and Enrica decide to "steal" one and take the man around Rome. To thank them, Dr. Williams agrees to operate on Lorenzo. Agnes, Oscar's daughter, returns to her father in the city, but the man is busy and can't go to the station, so Tommy goes. Libero finds a letter in which Maddalena writes to a certain Francesco and, unaware that she is the Pope, believes that she is in love with the gardener of the parish she frequents. Valerio assures Lele that he will leave her family alone, but Anna finds the man's invitation to the concert in a book by her. There the girl meets Geko.

Magdalene is summoned to the Vatican for a private audience with Pope Francis, but Elena and Bobò have a hand in the summons letter. Anna, meanwhile, continues her preparation for the admission tests to Medicine, but her meetings with Valerio and Geko are increasingly frequent.

Anna, accompanied by her grandparents and the lucky bear of the Martini family, takes the entrance exam for the Faculty of Medicine. Meanwhile, Lorenzo decides to admit Celeste, a young resident, into the operating room, but the girl panics and runs away.

Libero and Enrica invite Valerio to dinner to repay him. For this reason, Lele is forced to reveal the secret that binds him to the man. In the meantime, Lorenzo hires Andrea to renovate the new house, when Sara meets him she remembers the wild night she had with him.

Libero, still shaken by the revelation about Valerio, tries to attack the man, ordering him to stay away from Anna. Meanwhile Emiliano, at the suggestion of Ginevra, his new girlfriend, goes to Lele's clinic to give him the money he owes to the young Martini in order to end all relations with the past.

It's Anna's birthday. To celebrate, the young Martini gathers relatives and friends at her home, including Valerio and Geko. At the end of the evening Lele confesses the truth about Valerio and the paternity test to Libero, Enrica, Sara, Lorenzo and Maddalena.

Lele is determined to tell Anna the whole truth about Valerio, but can't find the right moment to address the conversation. Meanwhile, Sara and Lorenzo are invited by Federica, Andrea's wife, to the same bathhouse where Sara and Andrea spent their night out.

Anna, having discovered the truth about her real father, is shocked and decides to lock herself in her room to be alone and reflect. Meanwhile, the Martinis finally decide to build a second bathroom in the house, despite Libero's resistance.

Paolo, Bobò's best friend, reveals to Lele and Edoardo that he is gay and that he is at the mercy of the school bullies. Meanwhile, at the Martini house, Augusto appears, a plumber who immediately shows sympathy for Maddalena.

Anna is increasingly in crisis and has failed the entrance exam. Lele asks Carla to have Anna enroll in the Biology exam which, once passed, will give her access to the Faculty of Medicine.

Anna, on the eve of her exam, is spending the night at a disco. Tommy and Agnese who told their parents they were going to a school film screening, but they are at the abandoned factory.

In order to take revenge on Maddalena, Augusto brings a pestiferous nephew into the house who gets up to all kinds of things. After discovering Augusto's machination, Maddalena scolds him, but he tells her that they are now even and a draw.

Knowing the truth about Sara's betrayal, Lorenzo punches Andrea. Then he gives in to despair and gets drunk. Meanwhile, the financiers of the new surgery department arrive at the clinic, which will be directed by Lorenzo.

Ciccio returns to Rome to see a mare to buy. He is warmly welcomed by the whole family and goes with Lele to Valerio's loft where Geko's record is being presented.

On the plane to Berlin, Sara meets Matteo, a concert organizer who gets her two tickets for a deejay's show. Lorenzo, annoyed by that friendship, tells his wife that something between them is broken forever.

Made aware of the crisis with Lorenzo, Libero goes to the cottage to talk to Sara. The girl shows Libero a nearby grove but just then some gardeners from the Municipality arrive: the trees have to be cut down.

Maddalena, very worried about Rocco's situation, decides to go and look for him. Libero accompanies her, but when they arrive at the address indicated by Maddalena, they find a group of people in front of the door and an ambulance.

Rocco, who has installed himself bag and baggage in the Martini house, does nothing but eat and then lie down on the sofa. When he says he will look for a job, Augusto and Libero follow him and catch him while he is playing video poker.

Lorenzo manages to operate on a little girl with a heart malformation with his own. Celeste and Lorenzo are very happy and compliment each other. They leave the clinic together hand in hand, but Sara catches them in the act.

Lorenzo spent the night with Celeste. Sara decides to participate in the race run by the “Cuore a Cuore” association, but Lorenzo refuses to sign the eligibility form because he considers Sara's competitive activity too risky.

Jacinta goes to Poggiofiorito to meet Rocco and tell him that she intends to get back together with him; Rocco is about to give in when she notices the presence of Libero and Enrica who were spying on them.

Emiliano leaves the Raggio di Sole Center and finds Ginevra lifeless on the ground, after being run over. He calls an ambulance that takes the girl to Villa Aurora, where Lele is informed of the girl's identity.

It's the day of the final of the volleyball tournament. The boys are excited and excited, but realize their coach is distracted and has other things on her mind. Meanwhile Lorenzo receives an embittered message from Sara.