Eşref Rüya tells the story of a young man who is a prisoner of a love whose name he does not know. Çağatay Ulusoy plays the character Eşref, who is reckless, has everything but is a prisoner of a love whose name he does not know, while Demet Özdemir plays Nisan, the young musician who makes Eşref's heart skip a beat.

Nisan, who understands that she is in great danger once again with this incident, looks for ways to escape Çiğdem's games. Eşref cannot help but be carried away by feelings that he is unfamiliar with whenever he comes face to face with Nisan. Nisan's getting closer to Eşref causes alarm bells to ring for both of them. On the other hand, a great surprise awaits İzzet, who is drunk with victory. Eşref, who is preparing to make his enemies experience hell, will also face his new rival on the security front.

After İzzet’s death, Eşref now faces an even greater enemy. Horrified by everything that’s happened, Nisan prepares to make bold moves beyond her limits in order to finally end the game. Meanwhile, with his plans progressing as intended, Kadir is willing to betray the Yetimler to eliminate Eşref from the picture. On the law enforcement side, Serdar investigates the murder at the hotel and comes face to face with Eşref and the tribe. This tense confrontation—where everything could fall apart at any moment—sets the stage for an impending major conflict. Though Nisan plans to throw Eşref into the fire to save herself, seeing a different side of him pushes her into an unexpected dilemma. Her growing closeness with Eşref is about to land her in serious trouble.

Nimet’s abduction of Nisan and Afra signals that the war between the Yetimler and the tribe is far from over. Despite Serdar’s warnings, Eşref and Nusret continue to make moves that only fuel the fire of revenge between them. Kadir does everything he can to turn the Yetimler against Eşref. Meanwhile, his unexpected encounter with Nisan sparks unfamiliar emotions in Kadir’s heart. Eşref’s bold move to rescue Afra catches Nisan off guard. Now caught in a deep moral dilemma, will Nisan be willing to stain her hands with blood—if it means saving her sister’s life?

Kadir's appearance as a rival in his deepening relationship with Nisan upsets Eşref's balance. Meanwhile, when Nisan's closeness to Eşref draws the attention of the Gürdals, Nisan faces the risk of being exposed. While Eşref is convinced to end his feud with Nusret, a surprise development leads him to burn all ships. Eşref's final move will not only cause him to throw himself into the fire, but also his loved ones. Nisan will make a move that will shake Eşref's heart in order to prevent her secrets from being revealed.

Although Nisan is willing to turn down the opportunity she has for her career for Eşref, bigger surprises await her in the future. When the Yetimler's fight with the tribe begins to disturb the elders of the underworld, an unexpected development occurs for both sides. Meanwhile, Yakup Baba's worsening condition is a sign that there will be radical changes in the Yetimler. Kadir, who is doing everything he can to prevent Eşref from coming to power, has started to get closer to Nisan. Will Kadir, who is burning with love and lust for power, be able to risk betraying Eşref, who he promised to always stand by his side? Eşref, who agreed to confront Nusret Ağa at the point where the Orphans are in danger, will cause the balances to change again with a surprise move that will have an impact in the underworld.

Although Nisan is willing to turn down the opportunity she has for her career for Eşref, bigger surprises await her in the future. When the Yetimler's fight with the tribe begins to disturb the elders of the underworld, an unexpected development occurs for both sides. Meanwhile, Yakup Baba's worsening condition is a sign that there will be radical changes in the Yetimler.