Many of the town's citizens suffer from food poisoning. Police officers investigate and find out that the cause are poisoned apples sold by the Di Giacomos, a family of farmers. After some interrogations by Captain Anceschi, it seems that the family is not responsible for the case after all. Don Matteo's investigations lead him to a seasonal worker Di Giacomo's who seems to have motive.

A young soccer player dies of a drug overdose. Was it an accident or murder? The first person suspected by police officers is the owner of a tattoo shop who was in trouble with drug abuse before. The woman denies to be involved and Don Matteo tries to convince the police.

Nino Coronna is found in a garden of a villa, next to a corpse. The victim is the owner of the house, Giulia Chimenti's husband. Nino seems to be guilty and is immediately accused of homicide. Maresciallo Cecchini has to investigate alone because Captain Anceschi is a 'special friend' of Giulia. When Anceschi seems to be involved in the homicide, Don Matteo and Cecchini have to uncover the truth.

Monica, who believes to have cancer, meets the healer and magician Kaspar, who has a reputation of taking advantage of people in distress. After several healing sessions with Kaspar, Monica's medical condition improves. It's a miracle - and attracts many people to Kaspar's 'practice'. Police officers question Kaspar, but only Don Matteo's help leads them on the right track

A famous chef is killed. Police suspect the Bagnetti brothers, who were evicted by the chef and therefore have a motive. Gerolamo, a homeless man and witness of the homicide accuses Mordelli, another famous chef. Don Matteo thinks that the police in on the wrong track.

Maresciallo Cecchini is suspected to be a drug dealer! He supposedly only keeps his position as police officer to cover up his life of crime. Don Matteo and Captain Anceschi have to prove their friend's innocence.

Don Matteo is on a bus trip when a rich elderly lady is given a fatal shove. Don Matteo watches the scene but is too far away to recognize the guilty. Police investigations lead to the victim's nephew, who sold merchandise on the bus. Don Matteo finds out that the nephew is interested in more than just the inheritance.

A young boxer dies during training. Accident or homicide? The boy's trainer is accused of the crime. Don Matteo tries to solve the riddle.

A well known businessman is kidnapped. Who organized the abduction? Police seem to be on the right track and arrest an employee of the victim. While the son takes over his father’s business, Don Matteo finds out that many of the employees have bad interests…

Tarek, an immigrant, wants to traditionally arrange a wedding for his sons, who disagree with this tradition. To avoid the marriage, Mohammed commits a theft. When his brother Abdul gets involved in a violent crime, Don Matteo begins to investigate.

Sergio is run over by a car. His fiancée Angela mourns his death but decides to begin a new life. After joining a music band, she receives anonymous threats: Someone wants her to leave town. Police investigations lead to a young man who seems to be involved in the car accident. Don Matteo has to solve the case.

During a religious procession, Benito Lippi is bitten by a snake. Only an antidote can help to save his life, but it is hard to find since the snake is of a rare Asiatic breed. While police investigate who smuggled the snake into the country, suspicion falls on an oriental man who was seen near the victim during the procession.

During a walk in the woods, Nerino falls into a 'hole' and discovers an old Etruscan tomb, filled with treasures. When police officers arrive, the treasures have disappeared. Suspicion falls on Lanza, a surly man who was involved in a robbery before. But Don Matteo suspects a certain Mr. Todi.

A fire threatens the town. The culprit seems to be a little boy, Fabio, who immediately admits to be guilty. His father is convinced of his innocence and asks Don Matteo for help. It seems that the boy wanted to get his father's attention.

The town's volleyball team won the championship. During the celebration, Varoli, president and trainer of the team, is found dead. Vivana an ex-player of the team is suspected to have committed this crime because she has a motive: Since a car accident caused by Varoli, she is bound to a wheel chair. Don Matteo knows the girl and tries to prove her innocence.

A young woman is killed in her home. Natalina, the house keeper, can aid police investigations because she saw Giovanni Antonelli escaping from the house. The man admits that he had a relationship with the victim but refuses to confess to the crime. Police investigations move to a company, owned by the victim's 'real' boyfriend.

A laborer is found dead in the cement factory he works in. The suspect is the factory’s supervisor, who had differences with the victim. During research, Don Matteo and the police accidentally uncover a dramatic relationship.

The stables of an equestrian center catch fire. Suspicion falls on the old horse groom first, who has a motive to harm his employer. The employer, owner of the stables, might have a motive too - to collect insurance money. With Don Matteo's help and the aid of little boy Simone, the police uncovers the truth.

The manager of a country hotel is found dead. By chance, Don Matteo discovers that the victim blackmailed unsuspecting hotel guests with video recordings. Suspicion falls on a woman who seems to be involved. Her husband accuses himself.

The young woman Petra (Jacqueline Lustig), on the run from police after supposedly committing a crime, takes Don Matteo hostage. While the police and Don Matteo's 'family' attempt to free him, our protagonist cooks up a plan: In order to escape and to uncover the truth, he tries to become an accomplice to his kidnapper.

While Don Matteo investigates the attempted murder of an antique dealer, he finds himself taking care of Laura, a rebellious adolescent who is pregnant and currently staying at the rectory.

A girl dies at a rave party after having taken a drug that was cut badly. While Don Matteo and the Carabinieri are working on the investigation, Cecchini tries to prevent Tommasi and his daughter from spending a romantic weekend together all alone.

After a young woman dies in labor, the woman’s gynecologist is killed. Meanwhile, Tommasi is preparing for a boxing match and is forced to choose a coach - the ready and willing Cecchini or the professional MP Conti…

A falconer who adopted an autistic boy is stabbed to death. Meanwhile, due to a misunderstanding, Cecchini thinks he only has six months to live.

Don Matteo investigates the attempted murder of a woman who has re-emerged from the past. Meanwhile, the captain tries not to make a bad impression on the young, athletic Spanish friends that are staying at Patrizia’s house.

During a reception held at the mansion of a wealthy family, an unidentified body is found. The investigation brings the mysterious past of a loving nanny to the fore. Cecchini, instead, mistakenly believes Patrizia is pregnant, which leads to some comical misunderstandings.

A young woman staying at the rectory to complete the Via Francigena pilgrimage is strangled to death. Meanwhile, Cecchini instructs Severino on how to win over the woman of his dreams.

During a masquerade party for Carnival, a girl who strikingly resembles the daughter of the party hostess is attacked. Meanwhile, Tommasi is repelled by everything that has to do with Carnival and Natalina finds a new, noble, suitor.

A boy who seems to be from a drug addiction community in the city is found dead. Meanwhile, Tommasi buys Patrizia an engagement ring, but just when he is about to pop the question, things don’t go as he had planned.

An old celebrity from Gubbio is killed by a dose of insulin. Meanwhile, captain Tommasi must face MP Conti’s father, who has just arrived in Gubbio and thinks Tommasi is his daughter’s boyfriend.

There is a Robin Hood in Don Matteo’s gang that is accused of the attempted murder of a dishonest retired man. Meanwhile, Cecchini is trying to deal with his very taxing father-in-law, who demands doctoring and attention.

The author of a book written specifically to report local town gossip is found almost dead. Laura and Natalina become passionate about the scandalous book that produces overall discontent throughout the town.

Sister Mary is attacked and falls into a coma. Meanwhile, Natalina has left the rectory for the peace of the convent, which, however, has some surprises in store.

The stop mother of Assunta Cecchini’s best friend Valeria is found dead. The sergeant’s adolescent daughters idolize their reckless friend who, this time however, has really gotten herself into trouble.

The lead model of a fashion show for wedding gowns is almost suffocated to death in her bed. Meanwhile, Tommasi is at the wedding expo and is subjected to his mother and soon to be father-in-law’s bickering about the details of his wedding.

The murder of a prostitute is linked to the story of an orphan who is also a fencing champion who has found a new family in her trainer and her trainer’s husband. Meanwhile, Laura begins having second thoughts about abandoning her daughter.

Sonia, a poor teenage mother, has managed to start a new life by creating a booming business selling children’s wear and by helping other women going through hard times. The man she is about to marry, however, is under questioning for the murder of a maid who is also discovered to be a prostitute.

A boy caught in the middle of a custody battle between his parents suddenly disappears. The case brings up some sad childhood memories for MP Conti, who follows the case with particular interest.

A baker known for great generosity is murdered. The investigation points to his sister-in-law, a rebellious young woman whose sister, the baker’s wife, caught behaving intimately with her murdered husband.

A sixteen year old girl disappears into thin air with no evidence of how to find her. As the investigation proceeds, the girl’s parents realize they never really knew their daughter.

A deaf girl who is unable to make her own parents accept her disability, finds herself involved in the murder of the director of the factory she works in. The prime suspect is one of the girl’s friends whose job is to insert disabled people into the workplace.

A boy watches as his father is accused of attacking the girl he is in love with. It’s up to Don Matteo to help father and son re-establish their relationship.

A factory worker, who lives with his wife in a tent and who was unjustly fired after a lifetime of work, is found dead.

The father of Laura’s daughter arrives in Gubbio. The young man’s parents demand custody of their grandchild at all costs. Laura and Don Matteo are at odds, but soon after the priest falls victim to deceit and is accused of harassment and even murder.