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Sydney Wells, at the start of the film, is a successful classical violinist, although blind since the age of 5. She and her sister had been playing with fireworks and they had been set off too close to her face, damaging her corneas.

Now, nearly 20 years later, Sydney undergoes a cornea transplant which causes her vision, albeit blurry, to begin returning. At first, she is confused and disoriented, unable to understand if what she sees is "real" or not. During her first night with her new eyes, her bedmate at the hospital dies, and Sydney, not understanding, watches her blurry figure being led away by someone else. During her stay, she also befriends a young girl named Alicia, who is there undergoing surgery for a brain tumor.

As time goes on, Sydney's vision begins to clear up and she struggles to understand the new world around her. Her therapist, Paul Faulkner, feels that her strange visions are her mind's way of interpreting what it was never able to before: including visions of fire, death, and the number '106'. Her bedroom walls keep changing to stone and back again, and she sees what appears to be the ghosts of people around her, including a young woman who walks right through her in the street just before she sees her body lying on the ground.

When a Chinese diner suddenly explodes around her, she finds herself in the charred remains. She learns that the accident that burned the diner down occurred weeks prior, revealing that her visions are of the past. Fleeing back to her apartment, she viciously smashes every light source and covers her windows (and eyes). Days later, her therapist forces his way in and removes her blinds, telling her to return to the real world.

Upon discovering that the face that appears in the mirror is not her own (which she finds out through photographs of her in the past), she becomes desperate to figure out who and what is sending her these visions. She begs Paul for help and finally convinces him to drive her to Mexico (at the risk of losing his medical license), in order to find out what happened to her donor, Ana Cristina Martinez.

They go to Ana Christina's house where they meet her mother, whose face looks slightly deformed. Sydney then sees a shadow behind Ana Christina's mother just as she has a heart attack. As Paul takes her to the hospital, Sydney goes into Ana Christina's room and sees more images. It turns out that young girl had committed suicide after failing to stop a factory fire that killed many of the people in the village and severely injured her own mother. After the fire, the deeply superstitious villagers, who had seen her crying outside the homes of people who were to die, believed she caused the disaster, and drove her to hang herself, calling her a witch and throwing stones at her.

Sydney and Paul return to the United States to discover the border is closed due to a high-speed chase on the other side. Dozens of vehicles are left stranded behind the closed gates. In the middle of the group of cars is a gas tanker with the number "106" on the front and a camper with a young girl in it. Sydney puts the pieces together and realizes the images she kept seeing - the number 106, the bells, and the girl trapped in a fire - weren't of the past, but of the future. She rushes out of the car, screaming at everyone to flee, telling them a bomb is on the bus. The people listen and flee, just as a car smashes through the police barriers and collides with the gas tanker. The tanker leaked its content and a spark caused by the car caused the tanker to explode, completely destroying every vehicle in a chain-reaction down the highway.

Small shards of glass from the explosion destroy Sydney's new corneas, a price she feels was small to pay in order to save the lives of everyone on the highway. Next we see Sydney in concert playing the violin. When she finishes, everyone including Helen and Paul, clap, and Sydney smiles. Credits roll.